Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.
As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting Collections DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relationship in XPG patients.Defects in XPG can cause either the cancer-prone condition xeroder